Basal forebrain cholinergic system volume is associated with general cognitive ability in the elderly
نویسندگان
چکیده
منابع مشابه
Interaction of basal forebrain cholinergic neurons with the glucocorticoid system in stress regulation and cognitive impairment
A substantial number of studies on basal forebrain (BF) cholinergic neurons (BFCN) have provided compelling evidence for their role in the etiology of stress, cognitive aging, Alzheimer's disease (AD), and other neurodegenerative diseases. BFCN project to a broad range of cortical sites and limbic structures, including the hippocampus, and are involved in stress and cognition. In particular, th...
متن کاملCholinergic depletion and basal forebrain volume in primary progressive aphasia
Primary progressive aphasia (PPA) is a heterogeneous syndrome with various neuropathological causes for which no medical treatment with proven efficacy exists. Basal forebrain (BF) volume loss has been reported in PPA but its relation to cholinergic depletion is still unclear. The primary objective of this study was to investigate whether cholinergic alterations occur in PPA variants and how th...
متن کاملEnhanced calcium buffering in F344 rat cholinergic basal forebrain neurons is associated with age-related cognitive impairment.
Alterations in neuronal Ca(2+) homeostasis are important determinants of age-related cognitive impairment. We examined the Ca(2+) influx, buffering, and electrophysiology of basal forebrain neurons in adult, middle-aged, and aged male F344 behaviorally assessed rats. Middle-aged and aged rats were characterized as cognitively impaired or unimpaired by water maze performance relative to young co...
متن کاملIs Life Expectancy Associated with Depression in the Elderly?
Introduction: Depression is one of the most common psychiatric disorders and risk factors for suicide in aging that often underdiagnosed and those who are more hopeful, suffer from less depression. The present study was conducted to determine the relationship between life expectancy and depression among older people in Yazd, Iran. Methods: This descriptive cross-sectional study was con...
متن کاملProfiles in Basal Forebrain Non-cholinergic Neurons
2 Intrinsic Voltage Dynamics Govern the Diversity of Spontaneous Firing 3 Profiles in Basal Forebrain Non-cholinergic Neurons 4 5 6 Saak V. Ovsepian, Oliver J. Dolly and Laszlo Zaborszky 7 8 (1) Centre for Molecular and Behavioral Neuroscience, Rutgers, The State University of 9 New Jersey, 197 University Avenue, Newark, NJ 07102, USA; (2) International Centre 10 for Neurotherapeutics, Research...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuropsychologia
سال: 2018
ISSN: 0028-3932
DOI: 10.1016/j.neuropsychologia.2018.08.005